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TitleDefining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.
Journal, issue, pagesScience, Vol. 374, Issue 6566, Page 472-478, Year 2021
Publish dateOct 22, 2021
AuthorsKathryn M Hastie / Haoyang Li / Daniel Bedinger / Sharon L Schendel / S Moses Dennison / Kan Li / Vamseedhar Rayaprolu / Xiaoying Yu / Colin Mann / Michelle Zandonatti / Ruben Diaz Avalos / Dawid Zyla / Tierra Buck / Sean Hui / Kelly Shaffer / Chitra Hariharan / Jieyun Yin / Eduardo Olmedillas / Adrian Enriquez / Diptiben Parekh / Milite Abraha / Elizabeth Feeney / Gillian Q Horn / / Yoann Aldon / Hanif Ali / Sanja Aracic / Ronald R Cobb / Ross S Federman / Joseph M Fernandez / Jacob Glanville / Robin Green / Gevorg Grigoryan / Ana G Lujan Hernandez / David D Ho / Kuan-Ying A Huang / John Ingraham / Weidong Jiang / Paul Kellam / Cheolmin Kim / Minsoo Kim / Hyeong Mi Kim / Chao Kong / Shelly J Krebs / Fei Lan / Guojun Lang / Sooyoung Lee / Cheuk Lun Leung / Junli Liu / Yanan Lu / Anna MacCamy / Andrew T McGuire / Anne L Palser / Terence H Rabbitts / Zahra Rikhtegaran Tehrani / Mohammad M Sajadi / Rogier W Sanders / Aaron K Sato / Liang Schweizer / Jimin Seo / Bingqing Shen / Jonne L Snitselaar / Leonidas Stamatatos / Yongcong Tan / Milan T Tomic / Marit J van Gils / Sawsan Youssef / Jian Yu / Tom Z Yuan / Qian Zhang / Bjoern Peters / Georgia D Tomaras / Timothy Germann / Erica Ollmann Saphire /
PubMed AbstractAntibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in ...Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses propagated in human-to-human transmission and spillover or spillback events between humans and animals. To develop prevention and therapeutic strategies, we formed an international consortium to map the epitope landscape on the SARS-CoV-2 spike protein, defining and structurally illustrating seven receptor binding domain (RBD)–directed antibody communities with distinct footprints and competition profiles. Pseudovirion-based neutralization assays reveal spike mutations, individually and clustered together in variants, that affect antibody function among the communities. Key classes of RBD-targeted antibodies maintain neutralization activity against these emerging SARS-CoV-2 variants. These results provide a framework for selecting antibody treatment cocktails and understanding how viral variants might affect antibody therapeutic efficacy.
External linksScience / PubMed:34554826 / PubMed Central
MethodsEM (single particle)
Resolution9.0 - 21.0 Å
Structure data

EMDB-24293:
Negative stain EM map of SARS-CoV-2 Spike in complex with human ACE2
Method: EM (single particle) / Resolution: 20.0 Å

EMDB-24335:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-259 IgG
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24336:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-186 IgG
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24337:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-199 IgG
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-24338:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-249 IgG
Method: EM (single particle) / Resolution: 19.0 Å

EMDB-24339:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-252 IgG
Method: EM (single particle) / Resolution: 17.0 Å

EMDB-24340:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-049 IgG
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-24341:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-073 scFv
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-24342:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-043 IgG
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24343:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-010 IgG
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24344:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-148 IgG
Method: EM (single particle) / Resolution: 19.0 Å

EMDB-24345:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-002 Fab
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-24346:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-80 IgG
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24348:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-081 Fab
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-24349:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-091 IgG
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24350:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-094 VHH-Fc
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-24351:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-096 IgG
Method: EM (single particle) / Resolution: 19.0 Å

EMDB-24352:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-250 Fab
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24353:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-063 scFv
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24354:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-021 Fab
Method: EM (single particle) / Resolution: 20.0 Å

EMDB-24355:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-247 IgG
Method: EM (single particle) / Resolution: 18.0 Å

EMDB-24356:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-020 Fab
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-24357:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-090 IgG
Method: EM (single particle) / Resolution: 21.0 Å

EMDB-24358:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-147 IgG
Method: EM (single particle) / Resolution: 19.0 Å

EMDB-24359:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-246 IgG
Method: EM (single particle) / Resolution: 19.0 Å

EMDB-24360:
EM map of SARS-CoV-2 Spike in complex with CoVIC-245 IgG
Method: EM (single particle) / Resolution: 9.0 Å

EMDB-24361:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-074 IgG
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24383:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-140 IgG
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24384:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-134 IgG
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-24388:
Negative stain EM map of SARS-CoV-2 Spike in complex with CoVIC-038 IgG
Method: EM (single particle) / Resolution: 18.0 Å

Source
  • Severe acute respiratory syndrome coronavirus 2

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