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TitleMemory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
Journal, issue, pagesbioRxiv, Year 2021
Publish dateMar 10, 2021
AuthorsPei Tong / Avneesh Gautam / Ian Windsor / Meghan Travers / Yuezhou Chen / Nicholas Garcia / Noah B Whiteman / Lindsay G A McKay / Felipe J N Lelis / Shaghayegh Habibi / Yongfei Cai / Linda J Rennick / W Paul Duprex / Kevin R McCarthy / Christy L Lavine / Teng Zuo / Junrui Lin / Adam Zuiani / Jared Feldman / Elizabeth A MacDonald / Blake M Hauser / Anthony Griffths / Michael S Seaman / Aaron G Schmidt / Bing Chen / Donna Neuberg / Goran Bajic / Stephen C Harrison / Duane R Wesemann /
PubMed AbstractMemory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with an unknown reach from original infection to antigenically drifted variants. We charted ...Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with an unknown reach from original infection to antigenically drifted variants. We charted memory B cell receptor-encoded monoclonal antibodies (mAbs) from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found 7 major mAb competition groups against epitopes recurrently targeted across individuals. Inclusion of published and newly determined structures of mAb-S complexes identified corresponding epitopic regions. Group assignment correlated with cross-CoV-reactivity breadth, neutralization potency, and convergent antibody signatures. mAbs that competed for binding the original S isolate bound differentially to S variants, suggesting the protective importance of otherwise-redundant recognition. The results furnish a global atlas of the S-specific memory B cell repertoire and illustrate properties conferring robustness against emerging SARS-CoV-2 variants.
External linksbioRxiv / PubMed:33758863 / PubMed Central
MethodsEM (single particle)
Resolution3.8 - 8.0 Å
Structure data

24192

7n62

EMDB-24192, PDB-7n62:
SARS-CoV-2 Spike (2P) in complex with C12C9 Fab (NTD local reconstruction)
Method: EM (single particle) / Resolution: 4.0 Å

24193

7n64

EMDB-24193, PDB-7n64:
SARS-CoV-2 Spike (2P) in complex with G32R7 Fab (RBD and NTD local reconstruction)
Method: EM (single particle) / Resolution: 4.2 Å

EMDB-24196:
SARS-CoV-2 spike (6P) in complex with C93D9 Fab
Method: EM (single particle) / Resolution: 7.1 Å

EMDB-24197:
SARS-CoV-2 spike (6P) in complex with C81C10 Fab
Method: EM (single particle) / Resolution: 8.0 Å

EMDB-24198:
SARS-CoV-2 spike (2P) in complex with C12A2 Fab
Method: EM (single particle) / Resolution: 3.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/Immune System / coronavirus / antibody / epitope / VIRAL PROTEIN / VIRAL PROTEIN-Immune System complex

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