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TitleStructure of the Cag type IV secretion system.
Journal, issue, pagesElife, Vol. 8, Year 2019
Publish dateJun 18, 2019
AuthorsJeong Min Chung / Michael J Sheedlo / Anne M Campbell / Neha Sawhney / Arwen E Frick-Cheng / Dana Borden Lacy / Timothy L Cover / Melanie D Ohi /
PubMed AbstractBacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Cag T4SS ...Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS assembly, which we describe as three sub-assemblies: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and central stalk. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system assemblies ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.
External linksElife / PubMed:31210639 / PubMed Central
MethodsEM (single particle)
Resolution3.5 - 5.4 Å
Structure data

20020

6odi

6oee

6oef

6oeg

6oeh

EMDB-20020: Reconstruction of a T4SS OMCC
PDB-6odi: Structure of CagY from a cryo-EM reconstruction of a T4SS
PDB-6oee: Structure of CagT from a cryo-EM reconstruction of a T4SS
PDB-6oef: PolyAla Model of the O-layer from the Type 4 Secretion System of H. pylori
PDB-6oeg: Structure of CagX from a cryo-EM reconstruction of a T4SS
PDB-6oeh: PolyAla Model of OMCC I-Layer
Method: EM (single particle) / Resolution: 3.8 Å

20021

6odj

EMDB-20021, PDB-6odj:
PolyAla Model of the PRC from the Type 4 Secretion System of H. pylori
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-20022:
Reconstruction of a T4SS OMCC
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-20023:
Reconstruction of a T4SS OMCC
Method: EM (single particle) / Resolution: 5.4 Å

Source
  • helicobacter pylori (bacteria)
KeywordsTRANSLOCASE / T4SS / Secretion / H. pylori

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