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TitleCryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues.
Journal, issue, pagesStructure, Vol. 14, Issue 3, Page 511-520, Year 2006
Publish dateAug 9, 2006
AuthorsPatricia Grob / Michael J Cruse / Carla Inouye / Marian Peris / Pawel A Penczek / Robert Tjian / Eva Nogales /
PubMed AbstractThe multisubunit transcription factor TFIID is essential for directing eukaryotic promoter recognition and mediating interactions with activators/cofactors during assembly of the preinitiation ...The multisubunit transcription factor TFIID is essential for directing eukaryotic promoter recognition and mediating interactions with activators/cofactors during assembly of the preinitiation complex. Despite its central role in transcription initiation and regulation, structural knowledge of the TFIID complex has so far been largely limited to electron microscopy studies of negatively stained samples. Here, we present a cryo-electron microscopy 3D reconstruction of the large endogenous human TFIID complex. The improved cryopreservation has allowed for a more detailed definition of the structural elements in the complex and for the detection, by an extensive statistical analysis of the data, of a conformational opening and closing of the cavity central to the TFIID architecture. We propose that these density rearrangements in the structure are a likely reflection of the plasticity of the interactions between TFIID and its many partner proteins.
External linksStructure / PubMed:16531235
MethodsEM (single particle)
Resolution32.0 - 35.0 Å
Structure data

EMDB-1194:
Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues.
Method: EM (single particle) / Resolution: 33.0 Å

EMDB-1195:
Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues.
Method: EM (single particle) / Resolution: 32.0 Å

EMDB-1196:
Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues.
Method: EM (single particle) / Resolution: 35.0 Å

Source
  • Homo sapiens (human)

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