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TitleHand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.
Journal, issue, pagesNat Commun, Vol. 11, Issue 1, Page 38, Year 2020
Publish dateJan 7, 2020
AuthorsYuguang Zhao / Daming Zhou / Tao Ni / Dimple Karia / Abhay Kotecha / Xiangxi Wang / Zihe Rao / E Yvonne Jones / Elizabeth E Fry / Jingshan Ren / David I Stuart /
PubMed AbstractCoxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently available. KREMEN1 (KRM1) is the entry ...Coxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently available. KREMEN1 (KRM1) is the entry receptor for the largest receptor-group of hand-foot-and-mouth disease causing viruses, which includes CV-A10. We report here structures of CV-A10 mature virus alone and in complex with KRM1 as well as of the CV-A10 A-particle. The receptor spans the viral canyon with a large footprint on the virus surface. The footprint has some overlap with that seen for the neonatal Fc receptor complexed with enterovirus E6 but is larger and distinct from that of another enterovirus receptor SCARB2. Reduced occupancy of a particle-stabilising pocket factor in the complexed virus and the presence of both unbound and expanded virus particles suggests receptor binding initiates a cascade of conformational changes that produces expanded particles primed for viral uncoating.
External linksNat Commun / PubMed:31911601 / PubMed Central
MethodsEM (single particle)
Resolution3.5 - 4.4 Å
Structure data

10242

6smg

EMDB-10242, PDB-6smg:
Structure of Coxsackievirus A10
Method: EM (single particle) / Resolution: 3.5 Å

10256

6snb

EMDB-10256, PDB-6snb:
Structure of Coxsackievirus A10 A-particle
Method: EM (single particle) / Resolution: 4.4 Å

10263

6snw

EMDB-10263, PDB-6snw:
Structure of Coxsackievirus A10 complexed with its receptor KREMEN1
Method: EM (single particle) / Resolution: 3.9 Å

Chemicals

ChemComp-SPH:
SPHINGOSINE

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • coxsackievirus a10
  • homo sapiens (human)
KeywordsVIRUS / CV-A10 / KREMEN1 / Virus-receptor complex / Hand / foot and mouth disease / picornavirus uncoating intermediate

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