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Structure paper

TitleAmino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus
Journal, issue, pagesTo Be Published
Publish dateJun 17, 2024 (structure data deposition date)
AuthorsYe M / Liang Z / Zhou D / Pike ACW / Wang S / Wang D / Bakshi S / Brooke L / Williams E / Elkins J ...Ye M / Liang Z / Zhou D / Pike ACW / Wang S / Wang D / Bakshi S / Brooke L / Williams E / Elkins J / Kessler B / Stuart DI / Sauer DB
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.79 - 3.5 Å
Structure data

50668

9fqt

EMDB-50668, PDB-9fqt:
Cryo-EM structure of MmCAT1 bound with FrMLV-RBD in the apo inward-open state
Method: EM (single particle) / Resolution: 3.5 Å

50669

9fqu

EMDB-50669, PDB-9fqu:
Cryo-EM structure of MmCAT1 bound with FrMLV-RBD in the arginine-bound inward-occluded state
Method: EM (single particle) / Resolution: 2.79 Å

50670

9fqv

EMDB-50670, PDB-9fqv:
Cryo-EM structure of MmCAT1 bound with FrMLV-RBD in the lysine-bound inward-occluded state
Method: EM (single particle) / Resolution: 2.95 Å

50671

9fqw

EMDB-50671, PDB-9fqw:
Cryo-EM structure of MmCAT1 bound with FrMLV-RBD in the ornithine-bound inward-occluded state
Method: EM (single particle) / Resolution: 3.01 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-ARG:
ARGININE

ChemComp-HOH:
WATER

ChemComp-LYS:
LYSINE

ChemComp-ORN:
L-ornithine

Source
  • mus musculus (house mouse)
  • murine leukemia virus
KeywordsMEMBRANE PROTEIN / MmCAT1 / FrMLV-RBD / SLC / viral tropism

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