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Title | Scaffold hopping identifies new triazole-and triazolium-based inhibitors of Leishmania infantum Trypanothione Reductase with potent and selective antileishmanial activity |
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Journal, issue, pages | To Be Published |
Publish date | Oct 26, 2019 (structure data deposition date) |
Authors | Revuelto, A. / de Lucio, H. / Carriles, A. / Garcia Soriano, J.C. / Sanchez-Murcia, P.A. / Hermoso, J.A. / Gago, F. / Camarasa, M.J. / Jimenez-Ruiz, A. / Velazquez, S. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-6t97: |
Chemicals | ChemComp-FAD: ChemComp-SO4: ChemComp-GOL: ChemComp-MWW: ChemComp-HOH: |
Source |
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Keywords | FLAVOPROTEIN / Inhibitor / Complex / Oxidoreductase / Leishmania / Drug |