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Structure paper

Titleinvestigating gatekeeper residues in prolyl hydroxyalse 2
Journal, issue, pagesTo Be Published
Publish dateJan 31, 2024 (structure data deposition date)
AuthorsFiorini, G. / Schofield, C.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.39 Å
Structure data

PDB-8rv1:
HIF prolyl hydroxylase 2 (PHD2) T387S variant bound to acetate (ACT) and hydroxylated Hypoxia-inducible Factor 2alpha (HIF2alpha)
Method: X-RAY DIFFRACTION / Resolution: 1.39 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / 2OG oxygenase / Prolyl hydroxylase / Oxygen sensing / hypoxia

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