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TitleCrystal structure of kinase domain of HER2 Exon 20 insertion mutant in complex with tucatinib
Journal, issue, pagesTo Be Published
Publish dateDec 12, 2023 (structure data deposition date)
AuthorsRana, N. / Campbell, J. / Dou, Y.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.48 Å
Structure data

PDB-8vb5:
Crystal structure of kinase domain of HER2 Exon 20 insertion mutant in complex with tucatinib
Method: X-RAY DIFFRACTION / Resolution: 1.48 Å

Chemicals

PDB-1aac:
AMICYANIN OXIDIZED, 1.31 ANGSTROMS

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Receptor tyrosine kinase / YVMA insertion / alpha-C helix / A-loop

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