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TitleTargeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in Systemic Sclerosis
Journal, issue, pagesTo Be Published
Publish dateMay 11, 2025 (structure data deposition date)
AuthorsGaule, T.G. / Simmons, K.J. / Walker, K. / DelGaldo, F. / Ross, R.L. / Viswambharan, H. / Krishnappa, J. / Pacey, J. / McPhillie, M. / Tomlinson, D.C. / Maqbool, A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.399 Å
Structure data

PDB-9r5y:
Crystal structure of the C-terminal domain of human TNC in complex with Adhiron 52
Method: X-RAY DIFFRACTION / Resolution: 1.399 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN / Complex / protein protein interaction / Inhibitor / extracellular matrix

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