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Structure paper

TitleA new pathway in central metabolism mediates nutrient control of development and antibiotic production by Streptomyces
Journal, issue, pagesBiorxiv, Year 2024
Publish dateMar 15, 2024 (structure data deposition date)
AuthorsLi, C. / Urem, M. / Kotsogianni, I. / Lau, J. / Elsayed, S.S. / Martin, N.I. / McNae, I.W. / Voskamp, P. / Mayer, C. / Rigali, S. ...Li, C. / Urem, M. / Kotsogianni, I. / Lau, J. / Elsayed, S.S. / Martin, N.I. / McNae, I.W. / Voskamp, P. / Mayer, C. / Rigali, S. / Pannu, N. / Abrahams, J.P. / Schada von Borzyskowski, L. / van Wezel, G.P.
External linksBiorxiv / Search PubMed
MethodsX-ray diffraction
Resolution1.69 - 2.59 Å
Structure data

PDB-9eol:
N-acetylglucosamine 6-phosphate dehydratase: inhibited 6-phosphogluconic acid state of NagS
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-9f7o:
N-acetylglucosamine 6-phosphate dehydratase: apo form of NagS
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-9f7v:
N-acetylglucosamine 6-phosphate dehydratase: GlcNAc6P substrate-bound state of NagS
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-6PG:
6-PHOSPHOGLUCONIC ACID

ChemComp-HOH:
WATER

ChemComp-16G:
2-acetamido-2-deoxy-6-O-phosphono-alpha-D-glucopyranose

Source
  • streptomyces coelicolor (bacteria)
KeywordsSUGAR BINDING PROTEIN / Central metabolism; Aminosugar dehydratase; GlcNac-6P; Aminosugar toxicity

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