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| Title | The Discovery of IRAK4 Inhibitor Clinical Candidates BMS-986126 and BMS-986147 for the Treatment of Autoimmune Diseases |
|---|---|
| Journal, issue, pages | To Be Published |
| Publish date | Apr 5, 2023 (structure data deposition date) |
 Authors | Kumar, S.R. / Dudhgoankar, S. / Santella, J.B. / Paidi, V.R.R. / Nair, S. / Sistla, R. / Wu, H. / Gardner, D.S. / Stachura, S. / Cavallaro, C.L. ...Kumar, S.R. / Dudhgoankar, S. / Santella, J.B. / Paidi, V.R.R. / Nair, S. / Sistla, R. / Wu, H. / Gardner, D.S. / Stachura, S. / Cavallaro, C.L. / Brown, G.D. / Pitts, W.J. / Kempson, J. / Tebben, A.J. / Tokarski, J.S. / Zhu, X. / Carman, J.A. / Foster, K. / Caceres Cortes, J. / Everlof, G. / Galella, M.A. / Sarjeant, A. / Holloway, D.A. / Fan, L. / Li, X. / Chaudhry, C. / Locke, G. / Chimalakondra, A. / Mariappan, T.T. / Ruepp, S. / Elzinga, P.A. / Saxena, A. / Xie, D. / Kiefer, S.E. / Yan, C. / Newitt, J.A. / Ghosh, K. / Anumula, R.K. / Sack, J.S. / Tino, J.A. / Carter, P.H. / Hynes, J. / Duncia, J.V. |
 External links | Search PubMed |
| Methods | X-ray diffraction |
| Resolution | 1.89 - 2.76 Å |
| Structure data |  PDB-8sce:  PDB-8scv:  PDB-8scw: |
| Chemicals | 
ChemComp-ZVD:  ChemComp-SO4:  ChemComp-HOH:
ChemComp-ZVG:
ChemComp-ZVA: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / IRAK4 / ligand / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)