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TitleDipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
Journal, issue, pagesBiorxiv, Year 2020
Publish dateMar 12, 2019 (structure data deposition date)
AuthorsSilva-Garcia, M. / Bolgi, O. / Ross, B. / Pilla, E. / Kari, V. / Killisch, M. / Stark, N. / Lenz, C. / Spitzner, M. / Gorrell, M.D. ...Silva-Garcia, M. / Bolgi, O. / Ross, B. / Pilla, E. / Kari, V. / Killisch, M. / Stark, N. / Lenz, C. / Spitzner, M. / Gorrell, M.D. / Grade, M. / Urlaub, H. / Dobbelstein, M. / Huber, R. / Geiss-Friedlander, R.
External linksBiorxiv / Search PubMed
MethodsX-ray diffraction
Resolution3 - 3.2 Å
Structure data

PDB-6qzv:
DPP9 bound to a dipeptide (MP) from the N-terminus of BRCA2
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-6qzw:
DPP8 bound to a dipeptide (MP) from the N-terminus of BRCA2
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsHYDROLASE / DPP8 / DPP9 / BRCA2 / dipeptide

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