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TitleInhibition of the GES-2 beta-Lactamse by Tazobactam: Detection of Reaction Intermediates by UV and Mass Spectrometry and X-Ray Crystallography
Journal, issue, pagesTo be Published
Publish dateJun 15, 2010 (structure data deposition date)
AuthorsFrase, H. / Smith, C.A. / Toth, M. / Champion, M.M. / Mobashery, S. / Vakulenko, S.B.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.65 Å
Structure data

PDB-3nia:
GES-2 carbapenemase tazobactam complex
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-TBE:
TAZOBACTAM INTERMEDIATE

ChemComp-TF7:
(3S)-3-(dihydroxy-lambda~4~-sulfanyl)-4-(1H-1,2,3-triazol-1-yl)-D-valine

ChemComp-HOH:
WATER

Source
  • pseudomonas aeruginosa (bacteria)
KeywordsHydrolase/Hydrolase Inhibitor / beta-lactamase / antibiotic resistance / carbapenemase / lactamase inhibitor / Hydrolase-Hydrolase Inhibitor complex

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