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Structure paper

TitleIdeal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues
Journal, issue, pagesTo Be Published
Publish dateJul 16, 2024 (structure data deposition date)
AuthorsMuller M / Niemeyer K / Ojha NK / Porav SA / Vinayagam D / Urban N / Buchau F / Oleinikov K / Makke M / Bauer CC ...Muller M / Niemeyer K / Ojha NK / Porav SA / Vinayagam D / Urban N / Buchau F / Oleinikov K / Makke M / Bauer CC / Johnson AJ / Muench SP / Zufall F / Bruns D / Schwarz Y / Raunser S / Leinders-Zufall T / Bon RS / Schaefe M / Thorn-Seshold O
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.6 - 2.9 Å
Structure data

51074

9g4y

EMDB-51074, PDB-9g4y:
TRPC5 in complex with photoswitch E-AzHC
Method: EM (single particle) / Resolution: 2.6 Å

51076

9g50

EMDB-51076, PDB-9g50:
TRPC5 in complex with photoswitch Z-AzHC
Method: EM (single particle) / Resolution: 2.9 Å

Chemicals

PDB-1iie:
HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN

ChemComp-ZN:
Unknown entry

PDB-1iif:
Unknown entry

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / photo-switch / inhibitor

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