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Structure paper

TitleStructural basis of tubulin and heterocyclic podophyllotoxins complex for anticancer agents with dual-binding sites
Journal, issue, pagesTo Be Published
Publish dateOct 4, 2023 (structure data deposition date)
AuthorsZhao, W.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-8wmu:
Structural basis of tubulin and heterocyclic podophyllotoxins complex for anticancer agents with dual-binding sites
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM


PDB Unreleased entry

PDB-1d55: Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • sus scrofa (pig)
KeywordsCELL CYCLE / tublin / inhibitor / two binding sites

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