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TitleSynthesis and biological activities of novel indole derivatives as potent and selective PPAR-gamma modulators
Journal, issue, pagesTO BE PUBLISHED
Publish dateNov 10, 2009 (structure data deposition date)
AuthorsLamotte, Y. / Martres, P. / Faucher, N. / Laroze, A. / Grillot, D. / Ancellin, N. / Saintillan, Y. / Beneton, V. / Gampe, R.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3kmg:
The X-ray Crystal Structure of PPAR-gamma in Complex with an Indole Derivative Modulator, GSK538, and an SRC-1 Peptide
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-538:
4'-[(2,3-dimethyl-5-{[(1S)-1-phenylpropyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PPAR-gamma / Peroxisome proliferator-activated receptor / Telmisartan / Diabetes / Modulator / Activator / Diabetes mellitus / Disease mutation / DNA-binding / Metal-binding / Nucleus / Obesity / Phosphoprotein / Receptor / Transcription regulation / Zinc-finger

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