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Structure paper

TitleStructural basis of a homo-dimerization site in tetraspanin CD9 targeted by a melanoma patient-derived antibody
Journal, issue, pagesTo Be Published
Publish dateMay 2, 2019 (structure data deposition date)
AuthorsNeviani, V. / Pos, W. / Schotte, R. / Wagner, K. / Go, D.M. / Fatmawati, C. / Kedde, M. / Claassen, Y.B. / Kroon-Batenburg, L. / Lutz, M. ...Neviani, V. / Pos, W. / Schotte, R. / Wagner, K. / Go, D.M. / Fatmawati, C. / Kedde, M. / Claassen, Y.B. / Kroon-Batenburg, L. / Lutz, M. / Verdegaal, E.M.E. / van der Burg, S.H. / Spits, H. / Gros, P.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.2 - 2.5 Å
Structure data

PDB-6rlm:
Crystal structure of AT1412dm Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6rlo:
Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / Fab / CD9-binding / affinity-improvement

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