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TitleMunc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes
Journal, issue, pagesNat Commun, Year 2025
Publish dateJan 2, 2025 (structure data deposition date)
AuthorsLiu CQ / Liu DX / Zheng X / Guan JL / Zhou XY / Zhang HK / Wang S / Li QB / Gan L / He J / Ma C
External linksNat Commun / Search PubMed
MethodsEM (single particle)
Resolution4.38 Å
Structure data

62922

9la9

EMDB-62922, PDB-9la9:
Munc13-4-Rab27a complex with GppNHp
Method: EM (single particle) / Resolution: 4.38 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

Source
  • homo sapiens (human)
KeywordsEXOCYTOSIS / Vesicle tethering / Familial hemophagocytic lymphohistiocytosis type 3 /FHL3 / Griscelli syndrome type 2 /GS2

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