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TitleDiscovery of Highly Potent and Selective PDE5 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
Journal, issue, pagesTo Be Published
Publish dateJan 16, 2024 (structure data deposition date)
AuthorsZhang, F.C. / Huang, Y.Y. / Luo, H.B. / Wu, Y.Y.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.46 Å
Structure data

PDB-8xww:
Crystal structure of the catalytic domain of human PDE5A complexed with 2-(3-chlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid
Method: X-RAY DIFFRACTION / Resolution: 2.46 Å

Chemicals


PDB Unreleased entry

PDB-1d5k: Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Inhibitor / Complex

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