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Structure paper

TitleStructural insights into a broadly reactive Nanobody that remodels the lagovirus HBGA pocket
Journal, issue, pagesTo Be Published
Publish dateOct 13, 2025 (structure data deposition date)
AuthorsKara, D. / Pancera, M. / Hassanzadeh, G. / Hartley-Tassell, L. / Haselhorst, T. / von Itzstein, M. / Hansman, G.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.37 - 2.09 Å
Structure data

PDB-9yp1:
Rabbit Hemorrhagic Disease Virus Czech P domain
Method: X-RAY DIFFRACTION / Resolution: 1.37 Å

PDB-9yp2:
Structure of HaCV P domain in complex with Nanobody 7
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NHE:
2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID / pH buffer*YM

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • rabbit hemorrhagic disease virus
  • hare calicivirus
  • vicugna pacos (alpaca)
KeywordsVIRAL PROTEIN / lagovirus / Nanobody / complex

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