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TitleDesign and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity
Journal, issue, pagesTo be Published
Publish dateJan 15, 2009 (structure data deposition date)
AuthorsWei, Y. / Letiran, A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3fv5:
Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-1EU:
1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsISOMERASE / topoisomerase IV B subunit complex / Antibiotic resistance / ATP-binding / Nucleotide-binding / Topoisomerase

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