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Structure paper

TitleDiscovery of a novel azaindole derivatives targeting the influenza PB2 cap binding region
Journal, issue, pagesTo Be Published
Publish dateApr 25, 2022 (structure data deposition date)
AuthorsZhang, Z. / Liu, X.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.521 Å
Structure data

PDB-7xme:
Structure of Influenza A virus polymerase basic protein 2 (PB2) with an azazindole derivative
Method: X-RAY DIFFRACTION / Resolution: 2.521 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-GIH:
(2~{S},3~{S})-3-[[5-dimethoxyphosphoryl-4-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid

ChemComp-HOH:
WATER

Source
  • influenza a virus (a/victoria/3/1975(h3n2))
KeywordsRNA BINDING PROTEIN / Inhibitor / Complex

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