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TitleCrystal Structure of Human Serine Threonine Kinase- 10 Bound to Novel Bosutinib Isoform 1, Previously Thought to be Bosutinib
Journal, issue, pagesTo be Published
Publish dateOct 1, 2012 (structure data deposition date)
AuthorsVollmar, M. / Szklarz, M. / Chaikuad, A. / Elkins, J. / Savitsky, P. / Azeez, K.A. / Salah, E. / Krojer, T. / Canning, P. / Muniz, J.R.C. ...Vollmar, M. / Szklarz, M. / Chaikuad, A. / Elkins, J. / Savitsky, P. / Azeez, K.A. / Salah, E. / Krojer, T. / Canning, P. / Muniz, J.R.C. / Bountra, C. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / von Delft, F. / Knapp, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-4bc6:
Crystal structure of human serine threonine kinase-10 bound to novel Bosutinib Isoform 1, previously thought to be Bosutinib
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-XZN:
4-[(3,5-DICHLORO-4-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE

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