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Structure paper

TitleHigh-resolution structure of human SHMT2 with covalently bound PLP (internal aldimine)
Journal, issue, pagesTo Be Published
Publish dateJul 9, 2025 (structure data deposition date)
AuthorsWarlich, A. / Ruszkowski, M. / Nawrot, D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.3 Å
Structure data

PDB-9rwd:
High-resolution structure of human SHMT2 with covalently bound PLP (internal aldimine)
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / tetrahydrofolate / one-carbon metabolism / cancer therapy target

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