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Structure paper

TitleA nonenzymatic effector disrupts Bacteroides cell wall homeostasis via OmpA targeting to mediate interbacterial competition
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Year 2025
Publish dateMay 5, 2025 (structure data deposition date)
AuthorsHe J / Gao X
External linksProc. Natl. Acad. Sci. USA / Search PubMed
MethodsEM (single particle) / X-ray diffraction
Resolution1.9 - 4.18 Å
Structure data

EMDB-64503: Bacteroides fragilis T6SS effector-immunity BteO-BtiO complex
Method: EM (single particle) / Resolution: 4.18 Å

PDB-9uu0:
The structure of Bacteroides fragilis T6SS effector BteO
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

PDB-9uu1:
Bacteroides fragilis T6SS immunity protein BtiO
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9uu2:
Outer membrane protein OmpA-c-like domain
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-IPA:
ISOPROPYL ALCOHOL

Source
  • bacteroides fragilis (bacteria)
  • escherichia coli (strain k12) (bacteria)
  • bacteroides fragilis nctc 9343 (bacteria)
KeywordsTOXIN / Bacteroides fragilis T6SS effector / ANTITOXIN / Bacteroides fragilis T6SS immunity protein / STRUCTURAL PROTEIN / Outer membrane protein OmpA-c-like domain

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