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TitleCrystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73
Journal, issue, pagesTo be published
Publish dateApr 21, 2023 (structure data deposition date)
AuthorsShaw, G.X. / Shi, G. / Cherry, S. / Needle, D. / Tropea, J.E. / Waugh, D.S. / Ji, X.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-8sl9:
Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-H73:
5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • francisella tularensis subsp. tularensis (bacteria)
KeywordsTRANSFERASE / Francisella tularensis / HPPK-DHPS / bisubstrate inhibitor / HP-73

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