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TitleOxidation of antidiabetic compounds by cytochrome P450 BM3
Journal, issue, pagesTo be published
Publish dateSep 14, 2018 (structure data deposition date)
AuthorsJeffreys, L. / Leys, D. / Munro, A.W.M.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.997 Å
Structure data

PDB-6hn8:
Structure of BM3 heme domain in complex with troglitazone
Method: X-RAY DIFFRACTION / Resolution: 1.997 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-TDZ:
(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE

ChemComp-HOH:
WATER

Source
  • bacillus megaterium (bacteria)
KeywordsOXIDOREDUCTASE / cytochrome P450 / monooxygenase / heme binding / antidiabetic / troglitazone

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