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TitleINhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
Journal, issue, pagesTo Be Published
Publish dateDec 6, 2016 (structure data deposition date)
AuthorsGuillard, S. / Kolasinska-Zwierz, P. / Debreczeni, J. / Breed, J. / Zhang, J. / Bery, N. / Marwood, R. / Tart, J. / Overman, R. / Stocki, P. ...Guillard, S. / Kolasinska-Zwierz, P. / Debreczeni, J. / Breed, J. / Zhang, J. / Bery, N. / Marwood, R. / Tart, J. / Overman, R. / Stocki, P. / Minstry, B. / Phillips, C. / Rabbitts, T. / Jackson, R. / Minter, R.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution3.22 Å
Structure data

PDB-5mlb:
Crystal structure of human RAS in complex with darpin K27
Method: X-RAY DIFFRACTION / Resolution: 3.22 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / RAS / darpin / nucleotide exchange / inhibition

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