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TitleThe role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
Journal, issue, pagesTo be Published
Publish dateApr 5, 2014 (structure data deposition date)
AuthorsTsoumpra, M.K. / Muniz, J.R.C. / Barnett, B.L. / Kwaasi, A.A. / Pilka, E.S. / Kavanagh, K.L. / Evdokimov, A. / Walter, R.L. / Ebetino, F.H. / von Delft, F. ...Tsoumpra, M.K. / Muniz, J.R.C. / Barnett, B.L. / Kwaasi, A.A. / Pilka, E.S. / Kavanagh, K.L. / Evdokimov, A. / Walter, R.L. / Ebetino, F.H. / von Delft, F. / Oppermann, U. / Russell, R.G.G. / Dunford, J.E.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.98 Å
Structure data

PDB-4q23:
The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

Chemicals

ChemComp-RIS:
1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID

ChemComp-MG:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ISOPRENE BIOSYNTHESIS / LIPID SYNTHESIS / STEROID BIOSYNTHESIS / ISOPRENOID PATHWAY / CHOLESTEROL SYNTHESIS / BISPHOSPHONATES / Alpha helical prenyltransferase / Isopentyl Pyrophosphate / Dimethylallyl Pyrophospahte

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