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Structure paper

TitleStructure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA
Journal, issue, pagesTo Be Published
Publish dateSep 1, 2022 (structure data deposition date)
AuthorsWu, S. / Sohn, J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.44 Å
Structure data

PDB-8ecc:
Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-VWX:
[[(2~{R},3~{R},4~{R},5~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / Transferase-DNA complex / cGAS / 5-pppI(2 / 5)pA / IMMUNE SYSTEM / TRANSFERASE

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