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TitleA peptide binder of E3 ligase adaptor SPOP disrupts oncogenic SPOP-protein interactions in kidney cancer cells.
Journal, issue, pagesChin. J. Chem., Vol. 39, Page 271-280, Year 2021
Publish dateSep 18, 2020 (structure data deposition date)
AuthorsWang, Z. / Zhang, H. / Chen, B. / Ouyang, T. / Zheng, T. / Zhou, R. / Dong, Z. / Huang, Y. / Zhang, T. / Jiang, H. ...Wang, Z. / Zhang, H. / Chen, B. / Ouyang, T. / Zheng, T. / Zhou, R. / Dong, Z. / Huang, Y. / Zhang, T. / Jiang, H. / Gan, J. / Luo, C. / Yang, C.-G.
External linksChin. J. Chem. / Search PubMed
MethodsX-ray diffraction
Resolution1.45 Å
Structure data

PDB-7d3d:
Crystal structure of SPOP bound with a peptide
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / ccRCC / E3 ligase adaptor SPOP / ubiquitination / SBC motif(F-pS-S/T-S/T;F is nonpolar / p is polar)

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