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TitleMolecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin
Journal, issue, pagesTo be Published
Publish dateSep 3, 2008 (structure data deposition date)
AuthorsGandhi, P.S. / Page, M.J. / Chen, Z. / Bush-Pelc, L. / Di Cera, E.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.4 - 2.75 Å
Structure data

PDB-3edx:
Crystal structure of the W215A/E217A mutant of murine thrombin
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3ee0:
Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1))
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsHYDROLASE / Serine protease / Acute phase / Blood coagulation / Cleavage on pair of basic residues / Gamma-carboxyglutamic acid / Glycoprotein / Kringle / Protease / Zymogen / Calcium / Disease mutation / Pharmaceutical / Polymorphism / Secreted

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