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Structure paper

TitleNew lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
Journal, issue, pagesTo be Published
Publish dateJun 23, 2014 (structure data deposition date)
AuthorsEbetino, F.H. / Lundy, M. / Kwaasi, A.A. / Dunford, J.E. / Duan, Z. / Triffitt, J. / Mazur, A. / Jeans, G. / Barnett, B.L. / Russell, R.G.G.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.59 Å
Structure data

PDB-4qpf:
New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

Chemicals

ChemComp-39L:
[1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / isoprene biosynthesis / lipid synthesis / steroid biosynthesis / isoprenoid pathway / cholesterol synthesis / bisphosphonate / all-alpha helical prenyltransferase / isopentyl pyrophosphate / dimethylallyl pyrophosphate

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