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Structure paper

TitleStructural Basis of Eg5 Inhibition by Monastrol
Journal, issue, pagesTO BE PUBLISHED
Publish dateAug 17, 2004 (structure data deposition date)
AuthorsMaliga, Z. / Mitchison, T.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-1x88:
Human Eg5 motor domain bound to Mg-ADP and monastrol
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-NAT:
ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / Switch II / Motor domain / Neck linker

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