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Title | Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 227, Page 113953-, Year 2022 |
Publish date | Mar 31, 2021 (structure data deposition date) |
Authors | Kong, B. / Zhu, Z. / Li, H. / Hong, Q. / Wang, C. / Ma, Y. / Zheng, W. / Jiang, F. / Zhang, Z. / Ran, T. ...Kong, B. / Zhu, Z. / Li, H. / Hong, Q. / Wang, C. / Ma, Y. / Zheng, W. / Jiang, F. / Zhang, Z. / Ran, T. / Bian, Y. / Yang, N. / Lu, T. / Zhu, J. / Tang, W. / Chen, Y. |
External links | Eur. J. Med. Chem. / Search PubMed |
Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | PDB-7eil: |
Chemicals | ChemComp-909: ChemComp-HOH: |
Source |
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Keywords | GENE REGULATION / Inhibitor / BRD4 / BD1 |