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TitleCrystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF
Journal, issue, pagesTo Be Published
Publish dateApr 21, 2016 (structure data deposition date)
AuthorsWang, R. / Yan, Z. / Lv, Z. / Ma, L. / Miao, Q. / Chen, Q. / Wang, F. / Li, J. / Miao, L.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-5jhh:
Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-RA0:
3-{3-[ethyl(quinolin-2-yl)amino]phenyl}propanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/TRANSCRIPTION/INHIBITOR / RhoA-inhibitor-ARHGEF11 ternary complex / target-based pharmaceutical design / SIGNALING PROTEIN-TRANSCRIPTION-INHIBITOR complex

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