タイトル | Targeting KAT6A/KAT6B dependencies in breast cancer with a novel selective, orally bioavailable KAT6 inhibitor, CTx-648/PF-9363 |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2022年6月17日 (構造データの登録日) |
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著者 | Sharma, S. / Chung, J. / Uryu, S. / Rickard, A. / Nady, N. / Cao, J. / Greasley, S.E. / Brodsky, O. / Khan, S. / Wang, H. ...Sharma, S. / Chung, J. / Uryu, S. / Rickard, A. / Nady, N. / Cao, J. / Greasley, S.E. / Brodsky, O. / Khan, S. / Wang, H. / Wang, Z. / Zhang, Y. / Tsaparikos, K. / Chen, L. / Mazurek, A. / Lapek, J. / Kung, P.P. / Sutton, S. / Richardson, P.A. / Greenwald, E. / Yamazaki, S. / Jones, R. / Maegley, K. / Bingham, P. / Lam, H. / Stupple, A.E. / Kamal, A. / Chueh, A. / Cuzzupe, A. / Morrow, B. / Ren, B. / Carrasco-Pozo, C. / Tan, T.W. / Bhuva, D. / Allan, E. / Surgenor, E. / Vaillant, F. / Pehlivanoglu, H. / Falk, H. / Whittle, J. / Newman, J.M. / Cursons, J. / Doherty, J.P. / White, K.L. / MacPherson, L. / Devlin, M. / Dennis, M.L. / Hattarki, M.K. / De Silva, M. / Camerino, M.A. / Butler, M.S. / Dolezal, O. / Pilling, P. / Foitzik, R. / Stupple, P.A. / Lagiakos, R. / Walker, S. / Hediyeh-Zadeh, S. / Nuttall, S. / Spall, S. / Charman, S.A. / Connor, T. / Peat, T.S. / Avery, V.M. / Bozikis, Y.E. / Yang, Y. / Zhang, M. / Monahan, B.J. / Voss, A.K. / Thomas, T. / Street, I.P. / Dawson, S.J. / Dawson, M. / Lindeman, G.J. / Davis, M. / Visvader, J.E. / Paul, T.A. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 2.58 Å |
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構造データ | PDB-8dd5: Crystal structure of KAT6A in complex with inhibitor CTx-648 (PF-9363) 手法: X-RAY DIFFRACTION / 解像度: 2.58 Å |
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化合物 | ChemComp-R7L: 2,6-dimethoxy-N-{4-methoxy-6-[(1H-pyrazol-1-yl)methyl]-1,2-benzoxazol-3-yl}benzene-1-sulfonamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / histone lysine aceyltransferase / Inhibitor complex / Cancer / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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