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Titlehuman Aldose Reductase in complex with SAR25
Journal, issue, pagesTo Be Published
Publish dateOct 1, 2019 (structure data deposition date)
AuthorsSandner, A. / Heine, A. / Klebe, G. / Diederich, W. / Scheer, F.M.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution0.93 Å
Structure data

PDB-6syw:
human Aldose Reductase in complex with SAR25
Method: X-RAY DIFFRACTION / Resolution: 0.93 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-CIT:
CITRIC ACID

ChemComp-M0K:
2-[2-(cyclopropylmethylcarbamoyl)-5-fluoranyl-phenoxy]ethanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Diabetes / transient binding pocket / diabetic late effects / polyol pathway / osmotic and oxidative stress / cofactor / NADPH / NADP+ / AKR1B1 / ALDR1 / ALR2

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