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Structure paper

TitleStructural studies on the PU.1 inhibitory mechanism by diamidine minor groove binders
Journal, issue, pagesTo Be Published
Publish dateJun 9, 2023 (structure data deposition date)
AuthorsTerrell, J.R. / Paul, A. / Ogbonna, E.N. / Farahat, A.A. / Poon, G.M.K. / Wilson, W.D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.66 - 3.08 Å
Structure data

PDB-8t4n:
DB1976 Bound to the DNA Sequence 5'-CGCGAATTCGCG-3
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-8uff:
Human PU.1 ETS-Domain (165-270) Bound to d(AATAAAAGGAAGTGGG) in Ternary Complex with DB1976
Method: X-RAY DIFFRACTION / Resolution: 1.66 Å

PDB-8ufk:
Human PU.1 ETS-Domain (165-270) Bound to d(AATAAAAGCGGAAGTG)
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

PDB-8ufz:
Human PU.1 ETS-Domain (165-270) Bound to d(AATAAAAGCGGAAGTG) in Ternary Complex with DB1976
Method: X-RAY DIFFRACTION / Resolution: 3.06 Å

PDB-8uhk:
Human PU.1 ETS-Domain (165-270) Bound to d(AAAATAAAAGGAAGTG)
Method: X-RAY DIFFRACTION / Resolution: 3.08 Å

Chemicals


ChemComp, No image

ChemComp-Y5U:
Unknown entry

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsDNA / ETS family / ETS / PU.1 / diamidine / minor groove binder / TRANSCRIPTION / transcription factor / protein-DNA complex / TRANSCRIPTION-DNA complex / minor-groove binder / small-molecule / transcription inhibition

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