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-Structure paper
Title | Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485 |
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Journal, issue, pages | To be Published |
Publish date | Jan 24, 2013 (structure data deposition date) |
Authors | Waring, M.J. / Bennett, S.N. / Boyd, S. / Campbell, L. / Davies, R.D.M. / Ogg, D.J. / Hargreaves, D. / Martin, N.G. / Robb, G. / Wilkinson, S. ...Waring, M.J. / Bennett, S.N. / Boyd, S. / Campbell, L. / Davies, R.D.M. / Ogg, D.J. / Hargreaves, D. / Martin, N.G. / Robb, G. / Wilkinson, S. / MacPaul, P. / Wood, J.M. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | PDB-4iwv: |
Chemicals | ChemComp-NA: ChemComp-GLC: ChemComp-1J9: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Allosteric Site / Catalysis / Enzyme Activation / Gene Expression Regulation / Glucokinase / Glucose / Homeostasis / Humans / Hypoglycemia / Kinetics / Biological / Models / Molecular / Mutation / Protein Conformation / Scattering / Radiation / X-Rays / TRANSFERASE-TRANSFERASE INHIBITOR complex |