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Structure paper

Titlea single amino-acid dictates the dynamics of the switch between active and inactive C-Src conformation
Journal, issue, pagesTo be Published
Publish dateAug 13, 2010 (structure data deposition date)
AuthorsBoubeva, R. / Pernot, L. / Cristiani, A. / Moretti, L. / Berteotti, A. / Perozzo, R. / Gervasio, F. / Scapozza, L.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.4 - 2.7 Å
Structure data

PDB-3oez:
crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain complexed with imatinib
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3of0:
crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-STI:
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE / medication*YM

ChemComp-ACT:
ACETATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
KeywordsTRANSFERASE / c-Src L317I mutant / tyrosine kinase / imatinib

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