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Structure paper

TitleStructure-function analysis of ARGX-117, a calcium- and pH-dependent clinical phase complement C2 blocking antibody
Journal, issue, pagesTo be published
Publish dateJul 5, 2022 (structure data deposition date)
AuthorsOlesen, H.G. / Andersen, G.R.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.8 - 1.85 Å
Structure data

PDB-8acf:
Structure of the argX-117 in complex with a complement C2 fragment at low pH
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8aci:
Structure of ARG-117 Fab in complex with a fragment of complement C2, neutral pH
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsIMMUNE SYSTEM / Innate immune system / complement / antibody

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