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TitleKinetic and Structural Studies on Atazanavir-specific I50L Drug-Resistant HIV-1 Protease Mutant
Journal, issue, pagesTo be Published
Publish dateSep 23, 2008 (structure data deposition date)
AuthorsPrabu-Jeyabalan, M. / King, N. / Bandaranayake, R. / Nalivaika, E. / Schiffer, C.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-3em3:
Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-478:
{3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER / protease inhibitor, medication*YM

ChemComp-HOH:
WATER

Source
  • hiv-1 m:b_arv2/sf2 (virus)
KeywordsHYDROLASE / protease inhibitor / hyper susceptibility / drug resistance / hiv / amprenavir / AIDS / Protease

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