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TitleEngineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules
Journal, issue, pagesBioconjug. Chem., Vol. 33, Page 2180-2188, Year 2022
Publish dateJul 18, 2022 (structure data deposition date)
AuthorsHsiao, C.Y. / Meng, J.L. / Hong, J.Z. / Ly, X.H. / Lin, M.H. / Chang, C.Y. / Nguyen, M.T.T. / Cheng, T.L. / Lin, W.W. / Burnouf, P.A. ...Hsiao, C.Y. / Meng, J.L. / Hong, J.Z. / Ly, X.H. / Lin, M.H. / Chang, C.Y. / Nguyen, M.T.T. / Cheng, T.L. / Lin, W.W. / Burnouf, P.A. / Al-Qaisi, T.S. / Liu, E.S. / Su, Y.C.
External linksBioconjug. Chem. / Search PubMed
MethodsX-ray diffraction
Resolution2.42 Å
Structure data

PDB-7yiz:
Crystal structure of anti-mPEG h15-2b Fab W104Y mutant
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

Chemicals

ChemComp-P15:
2,5,8,11,14,17-HEXAOXANONADECAN-19-OL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / methoxy polyethylene glycol / anti-mPEG antibody

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