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Titlec-KIT kinase domain in complex with sunitinib
Journal, issue, pagesTo Be Published
Publish dateFeb 15, 2024 (structure data deposition date)
AuthorsTeuber, A. / Niggenaber, J. / Kleinboelting, S.B. / Landel, I. / Warmuth, J. / Busick, D. / Mueller, M.P. / Bauer, S. / Rauh, D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-8s14:
c-KIT kinase domain in complex with sunitinib
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-B49:
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / stem cell factor receptor / inhibitor / GIST / sunitinib / cancer / resistance

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