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TitleCrystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate
Journal, issue, pagesTo be Published
Publish dateMay 15, 2013 (structure data deposition date)
AuthorsTsoumpra, M.K. / Muniz, J.R.C. / Barnett, B.L. / Pilka, E. / Kwaasi, A. / Kavanagh, K.L. / Evdokimov, A.G. / Walter, R.L. / Ebetino, F.H. / Oppermann, U. ...Tsoumpra, M.K. / Muniz, J.R.C. / Barnett, B.L. / Pilka, E. / Kwaasi, A. / Kavanagh, K.L. / Evdokimov, A.G. / Walter, R.L. / Ebetino, F.H. / Oppermann, U. / Russell, R.G.G. / Dunford, J.E.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.07 Å
Structure data

PDB-4kqu:
Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-IPE:
3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE

ChemComp-AHD:
4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Isoprene biosynthesis / Lipid synthesis / steroid biosynthesis / dimethylallyl pyrophosphate / Isoprenoid Pathway / Cholesterol Synthesis / Bisphosphonates

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