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TitleCrystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
Journal, issue, pagesTo be Published
Publish dateAug 22, 2013 (structure data deposition date)
AuthorsLuz, J.G. / Coghlan, M.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4mdd:
Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-29M:
N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / nuclear hormone receptor ligand binding domain

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