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TitleDiscovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase-2 (ALK2) for the Treatment of Fibrodysplasia Ossificans Progressiva
Journal, issue, pagesAcs Med. Chem. Lett., Year 2025
Publish dateJun 2, 2025 (structure data deposition date)
AuthorsUllrich, T. / Guth, S. / Arista, L. / Weiler, S. / Stiefl, N. / Teixeira-Fouchard, S. / Dekker, C. / Hinniger, A. / Head, V. / Kneissel, M. / Kramer, I.
External linksAcs Med. Chem. Lett. / Search PubMed
MethodsX-ray diffraction
Resolution1.748 Å
Structure data

PDB-9rda:
Cocrystal structure of Zilurgisertib bound to the ALK2-FKBP12 complex
Method: X-RAY DIFFRACTION / Resolution: 1.748 Å

Chemicals

PDB-1jfb:
X-ray structure of nitric oxide reductase (cytochrome P450nor) in the ferric resting state at atomic resolution

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase / inhibitor / complex

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