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Structure paper

TitlePHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC
Journal, issue, pagesNat Commun, Vol. 12, Page 6078-, Year 2021
Publish dateDec 2, 2018 (structure data deposition date)
AuthorsAppel, L.M. / Franke, V. / Bruno, M. / Grishkovskaya, I. / Kasiliauskaite, A. / Kaufmann, T. / Schoeberl, U.E. / Puchinger, M.G. / Kostrhon, S. / Ebenwaldner, C. ...Appel, L.M. / Franke, V. / Bruno, M. / Grishkovskaya, I. / Kasiliauskaite, A. / Kaufmann, T. / Schoeberl, U.E. / Puchinger, M.G. / Kostrhon, S. / Ebenwaldner, C. / Sebesta, M. / Beltzung, E. / Mechtler, K. / Lin, G. / Vlasova, A. / Leeb, M. / Pavri, R. / Stark, A. / Akalin, A. / Stefl, R. / Bernecky, C. / Djinovic-Carugo, K. / Slade, D.
External linksNat Commun / Search PubMed
MethodsX-ray diffraction
Resolution1.748 - 2.85 Å
Structure data

PDB-6ic8:
Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2
Method: X-RAY DIFFRACTION / Resolution: 1.929 Å

PDB-6ic9:
Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser7
Method: X-RAY DIFFRACTION / Resolution: 1.748 Å

PDB-6q2v:
Crystal structure of SPOC domain of human PHD-finger protein 3 (PHF3)
Method: X-RAY DIFFRACTION / Resolution: 2.594 Å

PDB-6q5y:
Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2Ser5
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / SPOC domain / PHF3 / pSER2 peptide / TRANSCRIPTION / Pol II / pSer2Ser5 peptide

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